San Francisco 49ers at Tennessee Titans Week 16 Odds & Free Pick

December 23, 8:20 PM EST

Betting Odds

Point Spread: 
SF -3.5/TEN +3.5

Two teams that are trending in different directions as of late hook up when the 49ers visit the Titans for this week's edition of NFL Thursday night betting action. San Francisco comes in with five wins over its last six games, while Tennessee owns three losses over its last four games.

Those trends are obviously apparent to the odds-makers and the betting public; the Niners are favored by a field goal on the road and going up.

How are we playing this game with our free NFL betting pick?

NFL Betting Lines

The Week 15 NFL betting odds opened the 49ers as three-point road favorites for Thursday night, with an over/under of right around 45. Early betting action then added a hook to that spread.

49ers-Titans NFL Betting Preview

San Francisco is 5-1 both SU and ATS over its last six games after beating Atlanta last Sunday 31-13. That game was tied at 10-10 when the 49ers scored the last seven points of the first half, then the first seven points of the second half, and held on from there for the victory and the cover as 10-point favorites.

The Niners out-gained the Falcons 397-275, out-rushed Atlanta 162-62, and played some great goal-line defense.

San Francisco has now out-gained and out-rushed five of its last six opponents.

At 8-6 overall, the 49ers probably won't catch Arizona in the NFC West race, but they also sit in the No. 6 spot in the NFC playoff standings, a game ahead of Minnesota and New Orleans.

Tennessee, meanwhile, is 1-3 both SU and ATS over its last four games after losing at Pittsburgh last Sunday 19-13. The Titans scored the first 10 points of that game, led 13-3 at the half but lost the second half 16-0 to lose the game.

In the end, driving for the winning score, Tennessee got stopped one yard short on a fourth down at the Steelers' 10-yard line.

The Titans actually out-gained Pittsburgh 318-168, out-rushed the Steelers 201-35, and dominated time of possession by a 39:21 split. But Tennessee also turned the ball over four times, which basically created a -12 points differential.

The Titans have out-gained three of their last four opponents and out-rushed each of their last four foes, even without RB Henry. But they're also -9 on the turnover margin over that span.

At 9-5 overall, Tennessee still leads the AFC South by one game over 8-6 Indianapolis and only trails Kansas City by one game in the battle for the No. 1 spot in the AFC. However, the Titans are certainly trending in the wrong direction, and there are five teams sitting just one game behind them in that AFC race at 8-6.

These two teams last met four seasons ago, a 25-23 San Francisco home win. Jimmy Garoppolo quarterbacked the Niners that day against Marcus Mariota for Tennessee.

On the injury front, the Titans will play this game without RB Henry and possibly without WR Jones.

NFL Betting Trends

  • Home teams are 106-112 SU, 95-123 ATS in the NFL this season.
  • Favorites are 135-85 SU, 104-116 ATS in the NFL this season.
  • This season, home dogs are 29-59 SU, 40-48 ATS in the NFL.

Totals Report

Totals are split 7-7 in 49ers games this season, which are averaging 48 total points.

Totals are split 7-7 in Titans games this season, which are averaging 46 points.

This season, the unders are a lopsided 121-99 (55 percent) in the NFL.

49ers vs. Titans Predictions 12/23/21

San Francisco is hot, Tennessee is not, which means a lot when handicapping this game. The 49ers are running the ball, getting good play at QB, and playing great defense. The Titans, meanwhile, just aren't the same team without Henry. So we like the 49ers here, minus the points.       

Free Pick: 
Take San Francisco -3.5